Modeling the onset and propagation of epileptiform activity in children

In epilepsy of childhood, diagnosis of a focal origin is crucial for therapeutical decisions. As a noninvasive method, MEG may supplement the information obtained during EEG video monitoring. Since MEG provides a higher sensitivity for interictal events, the task of source modeling is manifold: a) localize potential irritative onset zones in MEG; b) localize interictal onset and propagation in EEG; c) localize seizure onset in EEG; d) increase sensitivity of seizure identification in EEG by using information of MEG localization; e) use MEG localization to build regional hypotheses for high resolution MR imaging; f) compare spatio-temporal models of interictal and ictal activity and match with high resolution MR images. In this paper we will present our methological approach of multiple source analysis in children with partial epilepsies.